We encountered some issues with Kana - Little Sisters together on the Discord and after finding a resolution we compiled it here for you
Thanks to CanRanBan & Aglaophotis
Check the Windows Feature Menu if Media Features and Legacy Components are installed
Check if old DirectX versions are installed, if not install DirectX 9
Install https://github.com/Blinue/Magpie/releases & https://github.com/Nevcairiel/LAVFilters/releases (select everything with LAV in the name during install), Magpie will need .NET 6.0.4 Desktop Runtime (https://dotnet.microsoft.com/en-us/download/dotnet/thank-you/runtime-desktop-6.0.4-windows-x64-installer) and MSVC 2015-2022 Runtime (https://docs.microsoft.com/en-us/cpp/windows/latest-supported-vc-redist?view=msvc-170)
Install Kana - Little Sister on your C: drive in the Program Files (x86) folder
Start Magpie
Start Kana - Little Sister (if you see a blackscreen and the opening is not showing just click on the screen)
On the title screen press “Alt”, click “Screen(G)” & Windowed(W)
Now with Magpie running in the background press “Alt” & “F11” (or the shortcut you have set in Magpie)
Enjoy Kana - Little Sister in fullscreen