Hmm, I had a silly thought.
There are at least a couple of ‘lesbian’ eroges where the main character is a boy who has been turned into a girl by some magic/virus/whatever, right?
But picture this: What about a game where the PC is a girl, and all the other characters are boys who have been turned into girls by magic/virus/whatever?
Could be fun to play with gender from that perspective. The boys-turned-girls could have a wide range of reactions to their situations - one desperately trying to find a cure, one trying to make the best of it by being as butch as possible in her new body, one running wild trying to experience as many sensations as possible in her new body, one portraying a ridiculous caricature of kawaii femininity because she thinks she has to because she’s a girl now, one who barely seems to notice…
And for the PC, of course, some musing on whether this makes her (and them) lesbians or not, if she knows they were boys before, and if some of them might become boys again…