You probably already figured this out, but I’m kind of picky. There’s more or less three things that turn me off to a game of this sort:
1) Bad writing and/or localization. If the localization of a game is as bad as, say, Xenogears’ or FF7’s–then it’s hurt by it. Sometimes this can be overcome; Final Fantasy Tactics is a good example of this. Also, sometimes the original is just weak in the script department–this is different than a hack localization job; see Spriggan as an example of that.
2) Certain kinds of fetishes. I think I brought this up before, but I’m mildly microphobic–I don’t eat off of things others have, I don’t eat off the floor, I wash my hands frequently, etc. So there are certain kinds of fetishes that just…repel me. Water Closet is a good example of this.
3) Icky games. While I don’t object to what is usually termed extreme content when there’s a plot that revolves around it and it’s treated with the seriousness such topics have…I don’t really want to see it. And I have big big problems with works like Xchange (as if you didn’t know that) and Dragon Pink.